Motif ID: HOX{A4,D4}.p2

Z-value: 1.455


Transcription factors associated with HOX{A4,D4}.p2:

Gene SymbolEntrez IDGene Name
HOXA4 3201 homeobox A4
HOXD4 3233 homeobox D4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HOXA4chr7_-_27136876-0.486.2e-02Click!
HOXD4chr2_+_1767243580.224.2e-01Click!


Activity profile for motif HOX{A4,D4}.p2.

activity profile for motif HOX{A4,D4}.p2


Sorted Z-values histogram for motif HOX{A4,D4}.p2

Sorted Z-values for motif HOX{A4,D4}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A4,D4}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_16380967 3.412 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr6_+_105511615 3.149 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr4_+_74491272 2.353 ALB
albumin
chr3_-_121883647 2.065 HGD
homogentisate 1,2-dioxygenase
chr22_+_19458378 1.868 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr14_-_37133927 1.747 FOXA1
forkhead box A1
chr14_-_37134191 1.693 NM_004496
FOXA1
forkhead box A1
chr14_-_37134050 1.628 FOXA1
forkhead box A1
chr13_-_40491405 1.314 ELF1
E74-like factor 1 (ets domain transcription factor)
chr19_+_50100843 1.309 NM_000041
APOE
apolipoprotein E
chr1_-_108032645 1.210 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr20_+_31613800 1.157 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr17_-_53849888 1.144 RNF43
ring finger protein 43
chr10_-_69267774 1.143 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr2_+_171280046 1.142 NM_001003845
SP5
Sp5 transcription factor
chr2_+_171280182 1.122


chr17_+_50699965 1.118 HLF
hepatic leukemia factor
chr7_-_96471544 1.112 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr11_-_118405288 1.104 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr3_+_63928459 1.087 NM_001128149
ATXN7
ataxin 7
chr13_-_40491491 1.071 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr17_-_36418869 1.063 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr12_+_52105131 1.002 AMHR2
anti-Mullerian hormone receptor, type II
chr11_-_117589283 0.976 NM_153206
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr2_+_227900471 0.975 NM_020194
MFF
mitochondrial fission factor
chr9_+_263025 0.963 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr1_-_205272619 0.949 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr11_+_22644732 0.948 NM_001143830
GAS2
growth arrest-specific 2
chr4_+_74488947 0.935 ALB
albumin
chr7_+_72883128 0.931 NM_001305
CLDN4
claudin 4
chr12_+_69148120 0.926


chr5_+_67622242 0.916 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr1_-_205161821 0.893 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr4_+_74488910 0.880 ALB
albumin
chr12_-_23995220 0.871 SOX5
SRY (sex determining region Y)-box 5
chr16_+_56286212 0.865 NM_032269
CCDC135
coiled-coil domain containing 135
chr3_+_173043832 0.851 NM_001164436
TMEM212
transmembrane protein 212
chr5_-_168204430 0.833


chr2_+_127892489 0.825 PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr3_-_57209319 0.821 NM_003865
HESX1
HESX homeobox 1
chr1_+_165564904 0.817 NM_001198783
POU2F1
POU class 2 homeobox 1
chr12_-_23995109 0.815 SOX5
SRY (sex determining region Y)-box 5
chr1_-_36721501 0.806 NM_000760
NM_156039
NM_172313
CSF3R


colony stimulating factor 3 receptor (granulocyte)


chr17_-_53849929 0.796 NM_017763
RNF43
ring finger protein 43
chr2_-_203484445 0.794 WDR12
WD repeat domain 12
chr1_-_153537362 0.792 NM_181871
PKLR
pyruvate kinase, liver and RBC
chr1_-_143708467 0.789 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr2_-_180135559 0.782 NM_001113398
ZNF385B
zinc finger protein 385B
chr20_+_42463419 0.779 HNF4A
hepatocyte nuclear factor 4, alpha
chr3_-_121884091 0.773 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr5_-_16791346 0.773 MYO10
myosin X
chr12_-_10464308 0.757 NM_002261
NM_007333
KLRC3

killer cell lectin-like receptor subfamily C, member 3

chr16_+_4361775 0.756 NM_138440
VASN
vasorin
chr4_+_74488835 0.753 NM_000477
ALB
albumin
chr5_+_140454382 0.752 NM_018936
PCDHB2
protocadherin beta 2
chr2_+_127892459 0.751 NM_000312
PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr14_+_38804226 0.734 NM_203354
CTAGE5
CTAGE family, member 5
chr14_+_87560646 0.730 LOC283587
hypothetical protein LOC283587
chr1_+_165565006 0.729 POU2F1
POU class 2 homeobox 1
chr1_-_114215768 0.729 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr19_+_17723285 0.723 NM_001161359
NM_015122
FCHO1

FCH domain only 1

chr16_+_29597829 0.715 NM_014298
QPRT
quinolinate phosphoribosyltransferase
chr18_-_28606839 0.711 NM_020805
KLHL14
kelch-like 14 (Drosophila)
chr22_+_24468168 0.710 MYO18B
myosin XVIIIB
chr20_-_45410033 0.695 ZMYND8
zinc finger, MYND-type containing 8
chr2_+_38746555 0.694 NM_138801
GALM
galactose mutarotase (aldose 1-epimerase)
chr22_-_25205376 0.693 NM_152841
HPS4
Hermansky-Pudlak syndrome 4
chr5_-_132228375 0.685 NM_005260
GDF9
growth differentiation factor 9
chr8_-_38324809 0.685 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chrX_-_153698930 0.677 HMGN1P37
high-mobility group nucleosome binding domain 1 pseudogene 37
chr2_+_183290912 0.669 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr22_+_24468110 0.668 NM_032608
MYO18B
myosin XVIIIB
chr6_+_64289585 0.663 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr9_-_103185621 0.660 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr14_+_38772870 0.660 NM_054024
MIA2
melanoma inhibitory activity 2
chr2_-_165259334 0.655 COBLL1
COBL-like 1
chr19_-_53081326 0.649 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr6_+_64414389 0.642 NM_015153
PHF3
PHD finger protein 3
chr4_+_74520796 0.639 NM_001134
AFP
alpha-fetoprotein
chrX_+_9391314 0.628 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr4_+_100714995 0.628 MTTP
microsomal triglyceride transfer protein
chr12_-_120725210 0.624 LOC338799
hypothetical LOC338799
chr16_-_86527608 0.623 NM_001739
CA5A
carbonic anhydrase VA, mitochondrial
chr10_-_82039158 0.622 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr15_+_38082041 0.620 EIF2AK4
eukaryotic translation initiation factor 2 alpha kinase 4
chr5_-_139760838 0.618


chr8_+_22266256 0.616 PIWIL2
piwi-like 2 (Drosophila)
chr8_-_17797127 0.616 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr17_-_46140015 0.614 NM_052855
ANKRD40
ankyrin repeat domain 40
chr20_+_42463350 0.611 HNF4A
hepatocyte nuclear factor 4, alpha
chr7_+_106897737 0.605 NM_005295
GPR22
G protein-coupled receptor 22
chr10_-_52315390 0.604 A1CF
APOBEC1 complementation factor
chr20_+_41621079 0.603 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr7_-_132371208 0.603 EEF1G
eukaryotic translation elongation factor 1 gamma
chr19_-_53081383 0.600 NM_003167
SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr20_+_42463387 0.598 HNF4A
hepatocyte nuclear factor 4, alpha
chr3_-_47909001 0.595 MAP4
microtubule-associated protein 4
chr12_+_14429499 0.593 ATF7IP
activating transcription factor 7 interacting protein
chr8_-_145672525 0.591 NM_003923
FOXH1
forkhead box H1
chr19_+_12810258 0.575 NM_014975
MAST1
microtubule associated serine/threonine kinase 1
chr5_+_171553780 0.574 NM_001171183
EFCAB9
EF-hand calcium binding domain 9
chr11_-_64520964 0.572 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr20_-_10360569 0.570 NM_018848
MKKS
McKusick-Kaufman syndrome
chr4_-_151990061 0.569 LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr11_-_5227611 0.567 NM_000559
HBG1
HBG2
hemoglobin, gamma A
hemoglobin, gamma G
chr18_+_30810889 0.564 NM_001143826
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr4_+_95595419 0.564 PDLIM5
PDZ and LIM domain 5
chr15_-_32398220 0.564 NM_005135
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr12_-_101835510 0.563 NM_000277
PAH
phenylalanine hydroxylase
chr17_-_36232366 0.562 NM_000421
KRT10
keratin 10
chr19_-_51979838 0.562 NM_001145145
SLC1A5
solute carrier family 1 (neutral amino acid transporter), member 5
chrX_+_65300803 0.561 NM_001130860
NM_014799
HEPH

hephaestin

chr11_-_27450808 0.559 NM_018490
LGR4
leucine-rich repeat containing G protein-coupled receptor 4
chrX_-_10761729 0.557 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr3_-_52712639 0.556 NM_152932
GLT8D1
glycosyltransferase 8 domain containing 1
chr1_+_205328834 0.551 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr20_+_42463279 0.543 NM_000457
NM_178849
NM_178850
HNF4A


hepatocyte nuclear factor 4, alpha


chr2_+_172530120 0.543 HAT1
histone acetyltransferase 1
chr20_+_56897549 0.542 GNAS
GNAS complex locus
chr9_-_5822840 0.540 ERMP1
endoplasmic reticulum metallopeptidase 1
chr12_-_120276394 0.537 NM_001137559
ANAPC5
anaphase promoting complex subunit 5
chr15_+_64661560 0.536


chr1_-_93030538 0.534 NM_005665
EVI5
ecotropic viral integration site 5
chr12_+_53177789 0.533 NCKAP1L
NCK-associated protein 1-like
chr17_+_54587882 0.531 PRR11
proline rich 11
chr11_-_46569489 0.529 NM_017749
AMBRA1
autophagy/beclin-1 regulator 1
chr12_+_53177806 0.527 NCKAP1L
NCK-associated protein 1-like
chr12_-_52975823 0.521 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr2_-_233586164 0.517 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chr9_-_5823065 0.515 ERMP1
endoplasmic reticulum metallopeptidase 1
chr17_-_78599695 0.510 B3GNTL1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
chr20_+_56897631 0.508 GNAS
GNAS complex locus
chr4_+_39874921 0.507 NM_004310
RHOH
ras homolog gene family, member H
chr7_+_111850367 0.506 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr14_+_99555471 0.505 EVL
Enah/Vasp-like
chr2_+_201756048 0.498 CASP10
caspase 10, apoptosis-related cysteine peptidase
chr17_+_35148084 0.497 NM_001030002
GRB7
growth factor receptor-bound protein 7
chr12_-_52975777 0.496 NM_006163
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr17_-_61655915 0.492 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr13_+_92677012 0.490 NM_005708
GPC6
glypican 6
chr2_+_73911477 0.488 STAMBP
STAM binding protein
chr9_-_5823072 0.487 NM_024896
ERMP1
endoplasmic reticulum metallopeptidase 1
chr12_-_53153639 0.484 NM_144594
GTSF1
gametocyte specific factor 1
chr17_+_23818922 0.484


chr1_-_156923111 0.482 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr7_+_128802719 0.482 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr7_+_113853790 0.481 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr7_-_92693716 0.478 NM_001039372
HEPACAM2
HEPACAM family member 2
chr14_+_22859236 0.477 NM_004643
PABPN1
poly(A) binding protein, nuclear 1
chr3_+_186529376 0.474 MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr14_-_22974707 0.473 NM_000257
MYH7
myosin, heavy chain 7, cardiac muscle, beta
chr6_-_138862271 0.473 NM_001144060
NHSL1
NHS-like 1
chr12_+_54808220 0.468 NM_001184796
NM_015292
ESYT1

extended synaptotagmin-like protein 1

chr2_+_102744921 0.467 NM_144632
TMEM182
transmembrane protein 182
chr6_-_42293575 0.466 MRPS10
mitochondrial ribosomal protein S10
chr14_-_80934523 0.463 NM_033104
STON2
stonin 2
chr12_+_54808344 0.462 ESYT1
extended synaptotagmin-like protein 1
chr6_-_138862273 0.461


chr6_+_32021742 0.458 CFB
complement factor B
chr1_+_40612891 0.455 NM_001198978
SMAP2
small ArfGAP2
chr6_+_32021687 0.454 NM_001710
CFB
complement factor B
chr12_+_53177758 0.452 NM_005337
NCKAP1L
NCK-associated protein 1-like
chr6_-_116973465 0.450 NM_001139444
BET3L
BET3 like (S. cerevisiae)
chr1_+_556968 0.450


chr12_+_54808310 0.448 ESYT1
extended synaptotagmin-like protein 1
chr12_+_99391870 0.448 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr12_+_54808316 0.447 ESYT1
extended synaptotagmin-like protein 1
chr7_-_33047042 0.447 NM_001166118
NM_016489
NT5C3

5'-nucleotidase, cytosolic III

chr17_-_38979178 0.445 NM_001079675
ETV4
ets variant 4
chr18_+_27210737 0.444 NM_001134453
NM_177986
DSG4

desmoglein 4

chr2_-_208702760 0.441 NM_020989
CRYGC
crystallin, gamma C
chr14_-_22496196 0.440 HAUS4
HAUS augmin-like complex, subunit 4
chr6_-_133161318 0.435 NM_052831
C6orf192
chromosome 6 open reading frame 192
chr10_-_52315436 0.434 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr3_+_63859114 0.433 NM_001177387
ATXN7
ataxin 7
chr19_-_56564068 0.433 NM_152353
CLDND2
claudin domain containing 2
chr17_-_35464414 0.430 NM_001079518
NM_014815
MED24

mediator complex subunit 24

chr19_-_56585603 0.430 NM_001193623
LOC147646
hypothetical protein LOC147646
chr11_+_5329313 0.428 NM_001004750
OR51B6
olfactory receptor, family 51, subfamily B, member 6
chr9_-_115877104 0.428 AMBP
alpha-1-microglobulin/bikunin precursor
chr9_+_94766379 0.426 FGD3
FYVE, RhoGEF and PH domain containing 3
chr15_+_97990705 0.426 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr2_+_169637255 0.426 NM_001142270
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr6_+_100161370 0.420 NM_021620
PRDM13
PR domain containing 13
chr19_+_54128750 0.417 NM_014475
DHDH
dihydrodiol dehydrogenase (dimeric)
chr20_-_30703219 0.415 NM_182584
C20orf203
chromosome 20 open reading frame 203
chr10_-_101831579 0.410 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr16_+_70654625 0.408 NM_020995
HPR
haptoglobin-related protein
chr6_+_126282078 0.406 NCOA7
nuclear receptor coactivator 7
chr11_-_66431910 0.405 NM_022172
PC
pyruvate carboxylase
chr10_+_86121526 0.401 FAM190B
family with sequence similarity 190, member B
chr12_-_52016270 0.399 NM_001173467
SP7
Sp7 transcription factor
chr1_-_154215558 0.399 ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr1_-_198643885 0.398 ZNF281
zinc finger protein 281
chrX_+_49718954 0.397 NM_000084
CLCN5
chloride channel 5
chr1_+_53253161 0.397 NM_001007099
NM_001007100
NM_001007250
SCP2


sterol carrier protein 2


chr11_-_5178505 0.397 NM_001004760
OR51V1
olfactory receptor, family 51, subfamily V, member 1
chr17_-_26648375 0.396 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chr10_+_11087345 0.396 CELF2
CUGBP, Elav-like family member 2
chr4_-_40212670 0.396 NM_019027
RBM47
RNA binding motif protein 47

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.